Diabetics are prone to several types of infections. One common
and serious infection is osteomyelitis, which is an inflammation of bone. Such
a problematic condition eventually causes death of the bone and surrounding
tissue, leading to amputation, IF NOT CAUGHT AND TREATED
EARLY. At the first sign of an
infection: redness, pus, inflammation,
heat and pain. Osteomyelitis is often
chronic in diabetics and must be constantly monitored. It is commonly spread from a foot ulcer to
the bone, if untreated. Signs of an infection of an ulcer include discharge, swelling, redness,
tenderness or pain, and warmth to touch. If not treated swiftly, this can most
definitely progress to osteomyelitis. Risk factors include deep wounds, neuropathy,
Charcot’s foot [loss of the internal orientation of the bones, exuberant bone
growth], poor blood circulation, poor control of sugar, and immune dysfunction.
The most common bacteria that cause osteomyelitis are Staph aureus. It is difficult to treat
this type of bacteria because it is part of what is known as a biofilm. This is
a community of bacteria protected by a matrix. The matrix is difficult to
penetrate and so many antibiotics cannot damage the bacteria. The antibiotic,
furthermore, must be able to also penetrate bone, which is the deepest tissue.
The most common antibiotics given for osteomyelitis are penicillin’s and the
closely related cephalosporins. If the patient has a penicillin allergy,
Clindamycin or Vancomycin can be given. The antibiotic is usually administered
with an IV in an outpatient setting. This is because the therapy must usually
be done for a long time, and it also prevents gastrointestinal problems. Along
with the antibiotic therapy, debridement or removal of the dead infected tissue
must be done in order to break down the biofilm of the bacteria. There is a relatively new antibiotic, linezolid
(Zyvox®) which is given orally and very effective for the treatment of a particularly
virulent type of Staph: MRSA (methicillin resistant staph
aureus).
Especially when the infection becomes chronic, surgery may be
necessary to treat osteomyelitis. Reconstruction of the limb is done in several
different ways depending on the progression of the infection. Sometimes
adjunctive therapy like revascularization of the limb or using hyperbaric
oxygen therapy (HBO) is useful. However, the best chance of a positive outcome is
when surgery, debridement, and antibiotics are used collectively.
At the first sign of a suspicious ulcer, drainage, a deep looking wound, consult your Podiatrist or PCP immediately.
Rao, Nalini, Ziran, Bruce, Lipsky,
Benjamin. “Treating Osteomyelitis: Antibiotics and Surgery.” American Society
of Plastic Surgeons Vol 127 Number 1S (2010): 177S-187S.